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Study on the relationship between glycosylated serum protein with the intrauterine fetal growth and metabolism axis
Author(s): GUO Lei, XIAO Zuo-yuan, LI Zhi-biao, TANG Xin-yi, ZHANG Xue-hua
Pages: 729-
731
Year: 2012
Issue:
10
Journal: New Medicine
Keyword: 糖化血清蛋白; 小于胎龄儿; 胰岛素; 胰岛素样生长因子-1;
Abstract: 目的:通过比较小于胎龄儿(SGA)与适于胎龄儿(AGA)的脐血糖化血清蛋白(GSP)水平,探讨GSP与胎儿发育及代谢轴之间的关系及检测新生儿GSP的意义.方法:以25例SGA为病例组,35例AGA为对照组,测量两组新生儿体格发育指标,检测脐血GSP水平及胰岛素、胰岛素样生长因子-1(IGF-1)等代谢轴相关因素并进行比较.结果:SGA组GSP、胰岛素、IGF-1水平低于对照组,组间差异均具统计学意义(P<0.05);GSP水平与出生体质量、身高、头围、BMI等体格发育指标呈正相关(r=0.632、0.676、0.628、0.432,P均<0.05).结论:SGA宫内血糖平均水平低于AGA,并同时存在低胰岛素及低IGF-I状态;GSP可以作为反映胎儿宫内发育情况及营养状态的指标.
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