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TET2 and DLK1 gene expression and their clinical significance in bone marrow CD3+ T cells of patients with myelodysplastic syndrome
Author(s): ZHANG Wei, FU Rong, WANG Hua-quan, LI Li-juan, YUE Lan-zhu, LIU Hui, QU Wen, LIANG Yong, WANG Guo-jin, WANG Xiao-ming, WU Yu-hong, LIU Hong, SONG Jia, GUAN Jing, XING Li-min, SHAO Zong-hong
Pages: 543-
546
Year: 2012
Issue:
7
Journal: Chinese Journal of Internal Medicine
Keyword: Myelodysplastic syndrome; CD3+ T cells; TET2 gene; DLK1 gene;
Abstract: 目的 探讨骨髓增生异常综合征(MDS)患者骨髓CD3+T细胞TET2及DLK1基因的表达水平及其临床意义,为进一步阐明MDS细胞免疫异常的机制提供依据.方法 应用免疫磁珠分选骨髓CD3+T细胞,应用实时荧光定量PCR(qPCR)检测26例MDS患者和16例正常对照骨髓CD3+T细胞中TET2和DLK1 mRNA的表达水平,分析它们与临床特征之间的相关性.结果 MDS患者骨髓CD3+ T细胞中TET2 mRNA表达是正常对照组的(0.16±0.15)倍(P<0.01);TET2mRNA表达水平与血清补体C3呈显著正相关(r =0.404,P<0.05);MDS患者骨髓CD3+T细胞中DLK1 mRNA表达是正常对照组的(1.61±0.88)倍(P<0.05);依据染色体分组,染色体异常组DLK1表达水平是染色体正常对照组的(1.45±0.44)倍(P<0.05);DLK1 mRNA表达水平与骨髓原始细胞比例呈显著正相关(r =0.343,P<0.05).结论 MDS患者骨髓CD3+T细胞中TET2 mRNA表达降低,DLK1 mRNA表达增高,提示CD3+T细胞有质的异常,这可能是导致机体免疫监视功能下降的机制之一.
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