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Thymoma T helper type 17 cells and related cytokines in myasthenia gravis
Author(s): 
Pages: 540-542
Year: Issue:  7
Journal: Chinese Journal of Internal Medicine

Keyword:  Myasthenia gravisThymomasT-Lymphocytesregulatory;
Abstract: 目的 研究伴胸腺瘤重症肌无力(MG)患者外周血中Th17细胞及其相关细胞因子变化.方法 采用流式细胞术检测MG患者及健康对照外周血单个核细胞(PBMCs) Thl7细胞比例,实时定量PCR检测PBMCs中Th17细胞相关细胞因子mRNA转录;ELISA检测血清中Th17细胞相关细胞因子表达.结果 MG伴胸腺瘤组外周血Th17细胞比例[(1.53±0.59)%]显著高于对照组[(0.94±0.32)%,P<0.05];MG伴胸腺瘤组IL-17 mRNA转录相对值显著高于对照组(23.7±4.5比13.4±3.2,P<0.01),IL-1β、IL-6及IL-23 mRNA转录量明显升高;MG伴胸腺瘤组血清IL-17表达量高于对照组[ (30.4±7.3) ng/L比(19.2±4.9) ng/L,P<0.05],IL-1β及IL-23表达量升高,与对照组相比差异有统计学意义.结论 MG胸腺瘤中Th17细胞增多,可能导致免疫调节功能紊乱,从而引起MG发病.
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