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Effect of 2, 5-hexanedione on light-molecular-weight neurofilaments (NF-L) degradation of rat nerve tissues
Author(s): ZOU Chao-shuang, XIE Ke-qin, KOU Rui-rui, GA0 Yuan, SONG Fu-yong
Pages: 418-
422
Year: 2012
Issue:
6
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: 2; 5-hexanedione; Nerve tissue; Sciatic nerve;
Abstract: 目的 研究2,5-己二酮(HD)对大鼠神经组织中低分子量神经丝(NF-L)降解的影响,探讨正己烷中毒性神经病发生的可能机制.方法 雄性Wistar大鼠50只随机分为1、2、3、4周染毒组和对照组,每组10只.经腹腔注射HD(400 mg/kg)染毒动物,剂量为,建立正己烷中毒性神经病模型.电子显微镜观察大鼠坐骨神经的超微结构变化,步态评分评价大鼠周围神经病症状的进展,免疫印迹法(Westem bl...
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