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Pulmonary toxicity in high-fat diet SD rats induced by intravenous injection of multi-walled carbon nanotuhes
Author(s): GU Xiao-min, HU Peng, SHEN Ting, XU Yu-ying, ZHANG Jun, ZHENG Yi-fan, YANG-Jun, ZHU Xin-qiang
Pages: 413-
417
Year: 2012
Issue:
6
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Multi-wall carbon nanotubes; Lung; Interleukin-1; Tumor necrosis factor; Pathology;
Abstract: 目的 探讨静脉注射多壁碳纳米管( MWCNTs)对高脂饮食SD大鼠肺组织的毒性.方法 将140只雄性SD大鼠随机分成正常对照组、高脂对照组、溶剂对照组、低剂量组(各30只),中、高剂量组(各10只).正常对照组给予正常饲料,其余各组在染毒前以70万U/kg维生素D3灌胃3d后予高脂饮食.溶剂组予含1% tween 80的生理盐水(0.2 ml/100 g)尾静脉注射,每周2次;低剂量组予MWCNT...
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