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Polymorphism of XRCC1 and chromosome damage in workers occupationally exposed to benzene
Author(s): 
Pages: 423-427
Year: Issue:  6
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases

Keyword:  BenzeneDNA damageMicronucleus testsPolymorphismsingle nucleotide;
Abstract: 目的 探讨DNA损伤修复基因—X线修复交叉互补基因1(XRCCI)多态性与苯致外周血淋巴细胞染色体损伤的关系.方法 采用胞质分裂阻滞微核试验方法评价459名苯接触工人和88名非接苯对照组工人染色体损伤水平,应用聚合酶链反应-限制性片段多态性技术检测XRCCI第6外显子194密码子,第9外显子280密码子和第10外显子399密码子多态.结果 接苯组微核发生率(2.12‰±1.88‰)明显高于对照组(...
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