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Development of animal model for lung injury in rats caused by unknown polymer via intratracheal instillation
Author(s): MA Zhan-fei, LI Xin-xin, WANG Ya-wen, WANG Di-xin, ZHENG Yu-xin, SUN Xin
Pages: 52-
58
Year: 2012
Issue:
1
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Polymer; Rats; Pleural effusion; Model; animal;
Abstract: 目的 建立未知聚合物气管滴注致SD大鼠肺组织损伤的动物模型,为探讨该未知聚合物职业暴露的损伤机制提供研究基础.方法 140只SD大鼠,随机分为5个染毒剂量组(40、30、20、10和5 mg/ml)及生理盐水对照组和动物空白对照组,每组20只.染毒组大鼠一次性气管滴注未知聚合物1.0 ml,左右肺各0.5 ml;生理盐水对照组大鼠一次性气管滴注生理盐水1.0 ml,左右肺各0.5 ml;动物空白对...
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