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Screen and validation of differentially expressing genes related to silicotic pulmonary fibrosis in rats
Author(s): XU Hui-rong, WANG Xian-hua, MA Xiao-bing, HOU Wen-na, ZHU Lan, XIANG Ju-cai, SUN Rui-jun
Pages: 45-
51
Year: 2012
Issue:
1
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Silicosis; Genes expression; Matrix metalloproteinase; Cathepsin E;
Abstract: 目的 筛选矽肺大鼠肺组织与正常大鼠肺组织的差异表达基因,并对差异表达基因基质金属蛋白每-12(MMP-12)和组织蛋白酶E(Cathepsin E)进行鉴定,探讨其在矽肺发病中的作用.方法 将健康SD大鼠随机分为模型组(24只)和对照组(6只),采用非气管暴露法建立雄性SD大鼠矽肺模型,HE染色和VG染色进行肺组织病理观察.对染尘60d的大鼠肺组织,应用基因芯片筛选大鼠肺组织中的差异表达基因.选择...
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