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The polymorphisms of XRCC1 gene and susceptibility to pulmonary cancer
Author(s): 
Pages: 41-44
Year: Issue:  1
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases

Keyword:  Lung cancerGenePolymorphismsSingle nucleotideDiseases susceptibility;
Abstract: 目的 探讨DNA修复基因XRCC1多态对肺癌发生易感性的影响.方法 采用病例对照研究的方法选择209例肺癌患者为病例组,256例健康检查者为对照组,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测XRCC1基因194、280和399位点的多态性.结果 病例组与对照组XRCC 1-194位点Trp/Trp变异基因型分布频率分别为19.1%、10.9%,两组比较,差异有统计学意义(P...
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