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Synthesis of tert-Butyl-4-Methyl-3-Oxopiperidine-1-Carboxylate
Author(s): 
Pages: 1021-1025
Year: Issue:  6
Journal: Journal of Chemical Engineering of Chinese Universities

Keyword:  1-叔丁羰基-4-甲基-3-哌啶酮3-羟基-4-甲基吡啶:SN2取代硼氢化还原Jones氧化;
Abstract: 1-叔丁羰基-4-甲基-3-哌啶酮是合成新型蛋白酪氨酸激酶Jak3抑制剂CP-690550的重要中间体,今以廉价易得的3-羟基-4-甲基吡啶和氯苄为原料,经过SN2取代反应,再经硼氢化还原生成N-苄基-3-羟基-4-甲基哌啶.过程中考察了溶剂对实验的影响,确定最佳溶剂为3.0 mol·L-1 NaOH水溶液,后经Jones氧化,Pd/C催化脱苄及酰基化反应,得到目标产物1-叔丁羰基-4-甲基-3-...
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