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Bioinformatics of Cow DRB3 Gene
Author(s): XU Fei, CHENG Shu-ru, LUO Yu-zhu
Pages: 4-
8
Year: 2011
Issue:
2
Journal: China Dairy Cattle
Keyword: 主要组织相容性复合体; DRB3基因; 生物信息学; 奶牛;
Abstract: 利用生物基因组学数据库,对奶牛MHC Ⅱ区DRB3基因进行生物信息学分析,以预测DRB3基因编码产物的理化性质、结构与功能,同时构建DRB3同源基因的系统进化树.结果表明,DRB3编码产物为不稳定亲水性蛋白,具有明显的信号肽,其切割位点位于29~30位的氨基酸之间.二级结构主要以无规则卷曲和延伸链为主,主要在细胞质中发挥生物学作用.序列分析表明,DRB3编码产物可能具有免疫应答、受体、胁迫应答、信...
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