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Effects of dexamethasone pretreatment on expression of matix metalloproteinase-9 in rats with acute lung injury induced by phosgene
Author(s): 
Pages: 289-293
Year: Issue:  4
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases

Keyword:  DexamethasonePhosgeneRespiratory distress syndromeMatrix metalloproteinase;
Abstract: 目的 探讨地塞米松对大鼠光气吸入性急性肺损伤(ALI)基质金属蛋白酶-9(MMP-9)表达的影响.方法 将SD大鼠随机分为3组:正常对照组(吸入与光气染毒组同等流量的空气)、光气染毒组(吸入8.33 mg/L的光气)、地塞米松预处理组(尾静脉注入2.5 mg/kg地塞米松1 h后,吸入8.33 mg/L的光气).染毒2 h后,收集支气管肺泡灌洗液(BALF)测定中性粒细胞细胞数、蛋白含量和肺湿/干...
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