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Effect of schisandrin B on lung mRNA expression of transforming growth factor-β1 signal transduction molecule in rat lungs exposed to silica
Author(s): FAN Lin-hua, LIU Tian-fu, GUO Min, LIU Mao-lin, WANG Zhi-ping, SI Su-jin
Pages: 255-
259
Year: 2011
Issue:
4
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Schisandrn Chinenisi; Silicon dioxide; Transforming growth factor beta; Gene expression;
Abstract: 目的 观察五味子乙素(sehisandrin B,Sch-B)对染矽尘大鼠肺组织转化生长因子β1(TGF-β1)信号通路分子mRNA表达的影响,探讨其防治矽肺纤维化的作用及机制.方法 将96只Wistar大鼠随机分为对照组、染矽尘组、Sch-B干预组,每组32只,气管暴露法一次性染尘建立大鼠矽肺模型,染矽尘组和Sch-B干预组每只大鼠气管内注入1 ml(50 mg/ml)SiO2混悬液,对照组注入...
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