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The study of effects of pirfenidone on the pulmonary fibrosis induced by paraquat in mice
Author(s): LI Jun-wei, SHEN Xiu-wei, SUN Wei, XIAO Min, TONG Shu-hua, YU Xi-chong, LU Zhong-qiu, HU Guo-xin
Pages: 87-
93
Year: 2011
Issue:
2
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Paraquat; Pulmonary fibrosis; Pirfenidone; Hydroxyproline; Transforming growth factor β;
Abstract: 目的 探讨吡非尼酮(PF)对百草枯(PQ)中毒小鼠肺纤维化的治疗作用,为临床治疗提供理论依据.方法 雄性ICR小鼠90只,随机分为正常对照组、PQ组、地塞米松组、25、50和100 mg/kgPF组,每组15只.正常对照组小鼠一次性空腹灌胃给予生理盐水,2 h后给予质量分数为1%羧甲基纤维素(CMC)灌胃,再每天定时空腹灌胃同等量CMC;PQ组、地塞米松组及各PF剂量组小鼠给予PQ100mg/kg...
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