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Effect of topical application of aminoguanidine cream on skin tissue of rats with diabetes
Author(s): 
Pages: 21-25
Year: Issue:  1
Journal: Chinese Journal of Burns

Keyword:  Diabetes mellitusGlycosylation end productsadvancedCell proliferationOxidative stressAminoguanidine;
Abstract: 目的 观察外敷氨基胍霜剂对糖尿病大鼠皮肤组织晚期糖基化终末产物(AGE)形成、KC细胞增殖及氧化应激的影响.方法 将硬脂酸、液状石蜡、凡士林、羊毛脂、肉豆蔻酸异丙酯、甘油、50 g/L尼泊金醇、盐酸氨基胍等试剂按一定比例混合制成氨基胍霜剂,以不含有氨基胍的霜剂为基质.取健康大鼠背部皮肤,分别用5、10 g/L氨基胍霜剂和5 g/L氨基胍+10g/L氮酮霜剂处理,于用药后2、4、7、10、12、24...
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