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Influence of galectin-3 on apoptosis of eosinophils and expression of Bcl-2 protein in lung tissue of asthmatic guinea pigs
Author(s): WANG Jing, HU Zhixiong
Pages: 575-
577,584,封3
Year: 2010
Issue:
9
Journal: New Chinese Medicine
Keyword: 半乳凝素-3; 哮喘; 嗜酸性粒细胞; 凋亡; Bcl-2; 豚鼠;
Abstract: 目的:探讨半乳凝素-3对哮喘豚鼠肺组织嗜酸性粒细胞凋亡及Bcl-2蛋白表达的影响.方法:36只豚鼠随机分为哮喘组、治疗组及对照组,每组12只.哮喘组及治疗组用卵白蛋白致敏和激发制作哮喘模型,对照组同期予生理盐水.于致敏第15~21日激发前1 h治疗组豚鼠予半乳凝素-3腹腔注射,剂量0.5 mg/kg,每日1次,连续7 d.测定3组豚鼠支气管肺泡灌洗液(BALF)中IL-5含量、嗜酸性粒细胞计数,苏...
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