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ji zhi jin shu dan bai mei -9 ji jin shu dan bai mei zu zhi yi zhi ji -1 bi li shi heng yu zhi qi guan xiao chuan
Author(s): 
Pages: 419-封3
Year: Issue:  6
Journal: New Chinese Medicine

Keyword:  基质金属蛋白酶-9金属蛋白酶组织抑制剂-1支气管哮喘气道重塑;
Abstract: 基质金属蛋白酶家族(MMPs)是生物进化中高度保守的一组锌离子依赖性蛋白水解酶,几乎能降解构成细胞外基质的所有成分,其中MMP-9与哮喘的关系最密切.金属蛋白酶组织抑制剂(TIMPs)家族是MMPs天然的内源性抑制因子,TIMP-1是TIMPs中活性最强并能特异性抑制MMP-9的活性.MMP-9/TIMP-1的动态平衡被视为反映气道组织破坏和修复的标志.
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