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Effects of 4-aminosalicylic acid on migration, activation and apoptosis of polymorphonuclear neutrophil in rats with experimental colitis
Author(s): 
Pages: 254-258
Year: Issue:  4
Journal: Chinese Journal of Digestion

Keyword:  Inflammatory bowel diseasep-aminosalicylic acidInterleukin-8Apoptosis;
Abstract: 目的 观察4-氨基水杨酸(4-ASA)对三硝基苯磺酸(TNBS)诱导的大鼠实验性结肠炎炎症损伤、肠组织一氧化氮合酶(iNOS)表达、血中性粒细胞(PMN)凋亡及血清白细胞介素(IL)-8水平等的影响,探讨4-ASA对炎症性肠病(IBD)的治疗作用及机制.方法 40只SD大鼠分为正常对照组(n=10)和实验组(n=30),实验组建立大鼠结肠炎模型.建模第5天将实验组按照处理方式分为实验对照组(n=1...
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