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Depolarization Induced by Substance P on Rat Stellate Ganglion Neurons
Author(s): 
Pages: 44-46
Year: Issue:  1
Journal: GUANGXI SCIENCES

Keyword:  substance Pstellate ganglionintracellular recording;
Abstract: The effects of neuropeptide substance P(SP) on the neurons of the isolated stellate ganglia of the rat were investigated by means of intracellular recording techniques.At the concentration of 1 μm to 10 μm,SP caused a low,monophersic depolarization in 28 out of 35 cells tested, low Ca2+ or tetrodotoxin (TTX)-containing Kreb's solution did not cause any significant change of the amplitude or duration of SP-induced depolarization.SP-induced depolarization was often associated with an increase in membrane resistance.Generally,the response was reversed on membrane potential of -80 mV to -100 mV.It is concluded that SP is excitatory to stellate ganglionic neurons and serves to augment impulse transmission through the neurons.These findings also suggest that a reduction of membrane K + conductance may underline the depolarization action of SP.
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