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Effects of imatinib mesylate on the expression of c-KIT in melanoma cell lines
Pages: 76-79
Year: Issue:  2
Journal: Journal of Clinical Dermatology

Keyword:  melanomac-KITimatinib mesylatestem cell factor;
Abstract: 目的:探讨甲磺酸伊马替尼对体外培养的人黑素瘤细胞系c-KIT表达及增殖的影响.方法:采用免疫组化和Western 印迹法检测人黑素瘤M14细胞和鼠黑索瘤B16F10细胞中c-KIT的表达,四甲基偶氮唑蓝(MTT)法分析3种浓度(5、10、20μmol/L)甲磺酸伊马替尼对M14细胞和B16F10细胞的生长抑制作用,Western印迹法观察M14细胞c-KIT和p-c-KIT蛋白的表达情况.结果:M...
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