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Effect of potassium iodide on prevention of experimental lead nephropathy and expression of nuclear factor-κB and fibronectin
Author(s): QIAO Yufeng, PANG Dongzuo, LU Jinfeng, HU Baizuo, LIU Dong, ZHOU Guifeng, YANG Bo, LI Rongshan, JIANG Yunsheng
Pages: 747-
752
Year: 2009
Issue:
12
Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases
Keyword: Potassium iodide; Lead; NF-κB; Connexins;
Abstract: 目的 观察碘化钾对染铅大鼠肾脏组织的核因子-κB(NF-κB)及纤维连接蛋白(FN)表达的影响.方法 SD大鼠72只适应性饲养1周,随机分为9组,每组8只,正常对照组,分别予蒸馏水喂饮1、2、3月;染铅组分别给予0.5%的醋酸铅喂饮1、2、3月;碘化钾组,在给予0.5%的醋酸铅喂饮的同时予碘化钾3 mg/100g体重,每天1次灌胃.用电子显微镜观察肾脏超微病理改变;用免疫组化的方法检测肾组织中NF...
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