Author(s): HE Jun, YANG Shucai, ZHANG Yafang
Pages: 34-37
Year: 2008 Issue:  1
Journal: Bulletin of Medical Research
Keyword:  Breast cancer; ICAM-1; LFA-1; Immunohistochemistry;
Abstract: Objective To explore the biological function of ICAM-1and LFA-1 in tumor metastasis,we observed the expression of ICAM-1(Intercellular Adhension Molecule-1)and LFA-1(Lymphocyte function related antigen-1)in cancer tissue and normal tissue.Methods A total of the samples were obtained from hospital,it includes 60 cases of breast cancer and 60 cases of normal mammary tissues.We observed the expression of ICAM-1 and LFA-1 by SP immunohistochemistry.We analyzed the relationship between the expression of ICAM-1,LFA-1and lymphatic vessel metastasis of breast cancer.Results The expression positive rate of ICAM-1and LFA-1 in breast cancer was obviously higher than that in normal mammary tissues(P<0.01).In breast cancer,the expression of ICAM-1 and LFA-1 in the group with lymph node metastasis,higher than that in the group without lymph node metastasis(P<0.05).The positive relativity of the expression was concluded between ICAM-1 and LFA-1 in breast cancer.Conclutions ICAM-1 and LFA-1 were related with breast cancer lymph metastasis and present synergism each other.It contribute to evaluate the competence of tumour metastasis,and have certainly instructive effect for the prevention and therapy of lymphatic vessel metastasis in breast cancer.