Recurrence and Metastasis of Hepatocellular Carcinoma-Clinical and Experimental studies
Author(s): ZHOU Xinda, LIU Yinkun
Pages: 11-14
Year: 2001 Issue: 3
Journal: Bulletin of Medical Research
Keyword: Hepatocellular carcinoma Recurrence Metastasis;
Abstract: Hepatocellular carcinoma (HCC) has become the second cause of cancer death in China. Surgery remains the best for a curative outcome of HCC. Unfortunately, recurrence and metastasis are major obstacles to further improve prognosis. Recently, studies on prevention and treatment of recurrence and metastasis after the resection of HCC have become attractive fields. This paper briefly reviewed the works done in the authors' institute. In clinical aspect, re - resection has been proved to prolong survival further in patients with subclinical recurrence, however, prevention of recurrence is difficult, postoperative chemoembolization (TACE), biotherapy, hepatic artery cannulation during operation and cryohepate-ctomy might help. In experimental aspect, a highly metastatic human HCC model in nude mice and metastatic human HCC cell line have been established. Invasiveness of HCC in molecular level has been investigated C - erb B2, p16, p21, p53, mdm-2, VEGF, TGFa, EGF receptor, MMP-2, μPA, μPA-R, PAI-1, ICAM - 1 were positively correlated and run - 23 - H1, TIMP - 2, Integrin α5, E - cadherin, Kai - 1 were negatively correlated Intervention using anti-sense H- ras, Suramin, Heparin, TNF - 470, anti CD3/HBx, BB94,β peptide etc. have also been found to inhibit tumor invasion and metastasis in experimental study. It is expected that biotherapy, novel approach based on molecular findings, multidisciplinary interventions might be important, and anti - angigoenic approach will be of particular implication for HCC.
Pages: 11-14
Year: 2001 Issue: 3
Journal: Bulletin of Medical Research
Keyword: Hepatocellular carcinoma Recurrence Metastasis;
Abstract: Hepatocellular carcinoma (HCC) has become the second cause of cancer death in China. Surgery remains the best for a curative outcome of HCC. Unfortunately, recurrence and metastasis are major obstacles to further improve prognosis. Recently, studies on prevention and treatment of recurrence and metastasis after the resection of HCC have become attractive fields. This paper briefly reviewed the works done in the authors' institute. In clinical aspect, re - resection has been proved to prolong survival further in patients with subclinical recurrence, however, prevention of recurrence is difficult, postoperative chemoembolization (TACE), biotherapy, hepatic artery cannulation during operation and cryohepate-ctomy might help. In experimental aspect, a highly metastatic human HCC model in nude mice and metastatic human HCC cell line have been established. Invasiveness of HCC in molecular level has been investigated C - erb B2, p16, p21, p53, mdm-2, VEGF, TGFa, EGF receptor, MMP-2, μPA, μPA-R, PAI-1, ICAM - 1 were positively correlated and run - 23 - H1, TIMP - 2, Integrin α5, E - cadherin, Kai - 1 were negatively correlated Intervention using anti-sense H- ras, Suramin, Heparin, TNF - 470, anti CD3/HBx, BB94,β peptide etc. have also been found to inhibit tumor invasion and metastasis in experimental study. It is expected that biotherapy, novel approach based on molecular findings, multidisciplinary interventions might be important, and anti - angigoenic approach will be of particular implication for HCC.
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