The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later.
We apologize for any inconvenience caused
Login  | Sign Up  |  Oriprobe Inc. Feed
China/Asia On Demand
Journal Articles
Laws/Policies/Regulations
Companies/Products
Bookmark and Share
The clinical and immunological study of the mizolastine on the eczema and atopic dermatitis
Author(s): 
Pages: 440-442
Year: Issue:  7
Journal: Journal of Clinical Dermatology

Keyword:  咪唑斯汀西替利嗪湿疹特应性皮炎;
Abstract: 目的:了解咪唑斯汀和西替利嗪治疗湿疹和特应性皮炎的有效性和安全性;并观察治疗前、后湿疹和特应性皮炎患者血清中白介素(IL)-4、IL-5、干扰素(IFN)-γ和肿瘤坏死因子(TNF)-α的水平变化.方法:采用随机对照方法,将患者随机分为咪唑斯汀组、西替利嗪组和对照组,外搽1%达克罗宁霜,治疗3周后观察、比较各组的疗效和安全性,并应用ELISA法检测治疗前、后湿疹和特应性皮炎患者的IL-4、IL-5、IFN-γ和TNF-α水平 .结果:入组前各组的症状、体征无明显差异.治疗后咪唑斯汀组疗效优于对照组和西替利嗪组.治疗前湿疹和特应性皮炎患者血清IL-4、IL-5和IFN-γ水平高于健康对照组,差异有统计学意义(P<0.05);而TNF-α水平与健康人差异无统计学意义(P>0.05);经咪唑斯汀和西替利嗪治疗后血清IL-4、IL-5和IFN-γ水平下降.结论:咪唑斯汀治疗特应性皮炎和湿疹安全、有效;咪唑斯汀对IL-4、IL-5的影响作用强于西替利嗪.
Related Articles
No related articles found