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Therapeutic efficacy of mizolastine in the treatment of psoriasis vulgaris: a randomised, double-blind and placebo controlled study
Author(s): 
Pages: 53-55
Year: Issue:  1
Journal: Journal of Clinical Dermatology

Keyword:  银屑病咪唑斯汀;
Abstract: 目的:探讨咪唑斯汀治疗寻常性银屑病的疗效及安全性.方法:采用随机、双盲、安慰剂对照的办法,观察咪唑斯汀治疗60例寻常性银屑病患者的疗效.试验组口服咪唑斯汀10mg/d,对照组服用安慰剂,两组患者均同时给予20%尿素霜外用,每日2次.结果:连续用药4周,试验组和对照组患者的银屑病皮损面积及严重度指数(PASI)评分均有不同程度的下降,治疗前、后PASI的差值试验组为(6.22±9.66)分(P<0.01),对照组为(1.78±3.48)分(P<0.05),试验组与对照组之间的差异有统计学意义(U=249.5,P=0.003);瘙痒程度视觉模拟尺法(VAS)积分治疗组显著降低(P<0.01),对照组改善不明显,两组之间的差异有统计学意义(U=165.0,P=0.000).所有患者均未出现严重不良反应.结论:咪唑斯汀治疗寻常性银屑病在改善其病情和减轻瘙痒症状等方面具有一定的疗效,可以作为一种安全有效的辅助治疗药物.
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