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Drug resistance of tuberculosis mycobacteria L forms and related gene mutation of tuberculosis patients with pneumoconiosis in Huainan mine area
Author(s): LU Jun, YE Song, LI Chao-pin
Pages: 369-
370
Year: 2007
Issue:
6
Journal: CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
Keyword: 尘肺; 结核; 肺; 分支杆菌; 基因;
Abstract: 目的 探讨尘肺并发结核患者感染的结核分支杆菌L型(MTB-L)的耐药性及耐药株基因突变情况.方法 在97例淮南矿区尘肺并发结核患者中分离出MTB-L52株,采用常规药敏试验(AST法)检测耐药性,采用聚合酶链反应-单链构象多态性分析(PCR-SSCP)法检测katG、rpoB和rpsL.耐药基因突变情况.结果 52株MTB-L对异烟肼(INH)、利福平(RFP)和链霉素(SM)的耐药率分别为76.92%(40/52)、90.38%(47/52)和50.00%(26/52),耐3种药物21例(40.38%),耐2种药物19例(36.54%),单耐药株12例(23.08%),耐药率100%.katG、rpoB和rpsL基因突变率分别为57.70%(30/52)、65.38%(32/52)和40.38%(21/52),52株MTB-L中有41株回复为MTB细菌型,回复率为78.85%(41/52),回复后耐药基因不变.PCR-SSCP法检出3个基因联合突变的有15株(15/52,28.84%),2个基因突变的16株(16/52,30.77%),单基因突变的6株(6/52,11.54%).结论 淮南矿区尘肺并发结核患者感染的MTB-L耐药情况严重,耐药率为100%,耐药株中存在katG、rpoB、rpsL耐药基因突变.
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