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The effects of mizolastine combined with detmatophagoides farinae injection on serum levels of CC chemokines in patients with chronic urticaria
Author(s): 
Pages: 215-217
Year: Issue:  4
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  荨麻疹趋化因子CC型特异性免疫治疗咪唑斯汀;
Abstract: 目的:研究粉尘螨特异性免疫治疗对慢性荨麻疹患者CC型趋化因子表达水平的影响,探讨特异性免疫治疗的作用机制.方法:将64例粉尘螨过敏的慢性荨麻疹患者随机分为两组,分别采用粉尘螨注射液联合咪唑斯汀治疗或单用咪唑斯汀治疗.应用双抗体夹心酶联免疫吸附试验(ELISA)检测治疗前、后以及正常对照血清中调节激活正常T细胞表达和分泌的细胞因子(RANTES)及单核细胞趋化蛋白-1(MCP-1)的水平.结果:两组慢性荨麻疹患者治疗前血清RANTES和MCP-1的水平均显著高于各自治疗后第16周末(P分别<0.001和0.05)及正常对照(P均<0.001);联合治疗组在治疗后第16周末的RANTES和MCP-1水平以及每周咪唑斯汀用量的评分均显著低于单用咪唑斯汀组(P<0.01).结论:RANTES和MCP-1在慢性荨麻疹的发病中起重要作用,特异性免疫治疗对慢性荨麻疹的治疗效果可能与其使RANTES和MCP-1下调的作用有关.
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