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The optimum concentration of aloesin to inhibit tyrosinase activity of human epidermal melanocytes
Author(s): 
Pages: 506-508
Year: Issue:  8
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  芦荟素黑素细胞酪氨酸酶黑素合成;
Abstract: 目的:研究抑制人表皮黑素细胞酪氨酸酶的芦荟素最佳浓度.方法:选择不同浓度的中药单体芦荟素(分别为0.010、0.001、0.100、1.000和10.000 mmol/L),作用于体外培养的人表皮黑素细胞,测定黑素细胞增殖率、酪氨酸酶活性和黑素含量.结果:10.000 mmol/L芦荟素组导致黑素细胞死亡;与正常对照组相比,芦荟素浓度大于0.100 mmol/L的黑素细胞增殖率明显下降(P<0.05);所有实验组黑素细胞的酪氨酸酶活性和黑素含量都显著降低(P<0.001).结论:低浓度的芦荟素(0.001~0.010 mmol/L)在不影响黑素细胞增殖的情况下可以显著抑制酪氨酸酶活性和黑素的合成.
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