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Determination of trichloroethylene induced DNA damage with 32P-Postlabeling
Author(s): HU Xunjun, LU Wei, WANG Wenjing, XIAO Ping, CHEN Liang
Pages: 427-
429
Year: 2006
Issue:
7
Journal: CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
Keyword: 三氯乙烯; DNA损伤; 加合物;
Abstract: 目的探讨三氯乙烯(TCE)4周静式吸入下对雄性大鼠所致DNA损伤.方法将TCE分为4个浓度组,对雄性大鼠静式吸入染毒,用32后标法检测肝脏组织和外周血白细胞(WBC)DNA损伤.结果与对照组比较,剂量组放射自显影指纹图多2~3个斑点;1~4周各剂量组肝脏组织和外周血WBC TCE-DNA加合物含量增加,与对照组比较,差异均有统计学意义(P<0.05);各浓度组TCE-DNA加合物含量均随TCE染毒剂量量的增加而增加,呈一定的线性趋势和剂量-效应关系;经4周染毒后再饲养1周的大鼠肝脏组织和外周血WBC TCE-DNA加合物各浓度组间差异无统计学意义(P>0.05);同一剂量组1~4周肝脏组织TCE-DNA加合物含量均先升高后降低再升高,而外周血WBCTCE-DNA加合物含量同一剂量组各时间点差异无统计学意义(P>0.05);各剂量组肝脏组织和外周血WBC TCE-DNA加合物相关性良好.结论4周静式吸入TCE对受试动物有一定的DNA损伤.
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