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Dynamic inhalation contamination installation in evaluation of detection of toxicity of liquid chemicals
Author(s): WANG Jing, YANG Yourun, FAN Weilin, MA Yongmin, LI Xin, LIU Yinghua
Pages: 435-
436
Year: 2006
Issue:
7
Journal: CHINESE JOURNAL OF INDUSTRIAL HYGIENE AND OCCUPATIONAL DISEASES
Keyword: 装置; 液体; 化学物; 毒性;
Abstract: 目的用动式吸入染毒装置检测化学物的吸入毒性.方法以某液体化学物(农药)为受试毒物,经雾化瓶向染毒柜内连续输送受试毒物空气,对大鼠进行吸入染毒,观察柜内毒物和温度、湿度的均衡性及毒物浓度上升时间;用该实验装置,采取一次最大剂量限度法进行4种农药的吸入毒性测定.结果实验数据经F检验,动物呼吸带对角线4位点毒气浓度均值差异无统计学意义(P>0.05);0、10 min与其后各时点毒气浓度差异有统计学意义(P<0.01,P<0.05),20 min后各时点毒气浓度差异无统计学意义(P>0.05);柜内温度、湿度有随染毒时间延长而升高的趋势,但变化在21℃±2℃,50%±3%范围内,其升高幅度未能影响毒物浓度的改变;4种农药的吸入毒性均为低毒,柜内受试物浓度恒定.结论在室温19℃~22℃、毒气流量1.0 m3/h条件下,柜内温度、湿度基本恒定,对毒物浓度无明显影响;柜内毒物浓度上升迅速,20 min内即趋于平衡;柜内毒物浓度分布均匀且变化小,2 h内基本稳定,能满足液体毒物的吸入毒性检测.
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