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Effects of latanoprost on vascular endothelial growth factor protein synthesis in human dermal papilla cells
Author(s): 
Pages: 283-285
Year: Issue:  5
Journal: JOURNAL OF CLINICAL DERMATOLOGY

Keyword:  毛乳头细胞血管内皮细胞生长因子拉坦前列素;
Abstract: 目的:观察拉坦前列素对培养的人毛乳头细胞增殖及其分泌血管内皮细胞生长因子(VEGF)的影响.方法:选择0.16、0.80 ng/mL和0.004、0.020、0.100μg/mL 5个浓度的拉坦前列素作用于体外培养的人毛乳头细胞72 h,采用四甲基偶氮唑蓝(MTT)法测定细胞增殖活性,ELISA法检测细胞分泌的VEGF水平.结果:与对照组相比,拉坦前列素对毛乳头细胞增殖无明显影响;加药组药物浓度达0.80 ng/mL时细胞分泌的VEGF水平明显升高,差异具有显著性,且升高水平与药物浓度之间呈剂量依赖关系.结论:拉坦前列素对毛乳头细胞增殖无明显影响,但能显著促进毛乳头细胞分泌VEGF,可能是通过VEGF促进毛发生长.
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