Molecular Detection of Brachyspina Syndrome in Holstein Cattle of Beijing Area
Author(s): LI Yanhua, YANG Chao, ZHU Yulin, LV Xiaoqing, LIU Lin, MA Zhu, ZHANG Shengli, SUN Dongxiao, QIAO Lv
Pages: 23-25,26
Year: 2016 Issue: 4
Journal: China Dairy Cattle
Keyword: Holstein cattle; Brachyspina syndrome; Gene frequency;
Abstract: Brachyspina syndrome (BS) is a rare monogenic autosomal recessive hereditary disorder identiifed in the Holsteins that causes either early-term abortion or stillborn calves when an individual is homozygous recessive for the lethal gene, leading to great economic loss in dairy farms. It is caused by a 3329bp deletion in the bovine Fanconi anemia complementation group I (FANCI ) gene on chromosome 21. In this study, DNA samples from Holstein cows (n=636) in Beijing district were detected by long- PCR. The frequency of carriers was 6.8% in the Holstein cattle sample and the allelic frequency of the BS deleted mutation in the population was 3.4%. Our pedigree studies of the carrier cattle revealed that the mutation inherited to him from Sweet Haven Tradition (USAM1682485, BY) which have many progeny in China. Although the elimination of BS-carrier bulls would be the most effcient method to control this genetic disorder, many BS-carrier bulls are still listed commercially for AI in China. Monitoring the prevalence of BS-carriers in random selected herds may be helpful in judging the effectiveness of the BS-control program.
Pages: 23-25,26
Year: 2016 Issue: 4
Journal: China Dairy Cattle
Keyword: Holstein cattle; Brachyspina syndrome; Gene frequency;
Abstract: Brachyspina syndrome (BS) is a rare monogenic autosomal recessive hereditary disorder identiifed in the Holsteins that causes either early-term abortion or stillborn calves when an individual is homozygous recessive for the lethal gene, leading to great economic loss in dairy farms. It is caused by a 3329bp deletion in the bovine Fanconi anemia complementation group I (FANCI ) gene on chromosome 21. In this study, DNA samples from Holstein cows (n=636) in Beijing district were detected by long- PCR. The frequency of carriers was 6.8% in the Holstein cattle sample and the allelic frequency of the BS deleted mutation in the population was 3.4%. Our pedigree studies of the carrier cattle revealed that the mutation inherited to him from Sweet Haven Tradition (USAM1682485, BY) which have many progeny in China. Although the elimination of BS-carrier bulls would be the most effcient method to control this genetic disorder, many BS-carrier bulls are still listed commercially for AI in China. Monitoring the prevalence of BS-carriers in random selected herds may be helpful in judging the effectiveness of the BS-control program.
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