Author(s): HUANG Yun, HU Wen-ji, LI Xue-jian, QIU Hong-cong, LIU Bu-ming, HUANG Yan, DU Zheng-cai, Scientific Experimental Center, Guangxi University of Chinese Medicine, Wuhan Hospital of Traditional Chinese Medicine, Guangxi Key Laboratory of Tradtitonal Chinese Medicine Quality Stardands
Pages: 616-619
Year: 2015 Issue:  6
Journal: Guangxi Sciences
Keyword:  mangiferin; mogroside; anti-inflammation; factorial analysis;
Abstract: 【Objective】The interaction effects between mangiferin and mogroside were investigated to explore their anti-inflammatory synergy.【Methods】Both mouse models of ear edema induced by xylene and increasing permeability of celiac capillary induced by acetic acid were employed to study the anti-inflammatory effects by means of factorial analysis of variance.【Results】Compared with blank control,anti-inflammatory effects of mangiferin are found in both mouse inflammatory models(P <0.05),whereas no anti-inflammatory effect of mogroside is found in any mouse inflammatory model(P >0.05).The anti-inflammatory effect in the group of mangiferin and mogroside is stronger than that in the group of mangiferin(P <0.01),andalso mangiferin and mogroside have interaction effects on anti-inflammatory synergy(P <0.05).【Conclusion】In expectorant test,there exists interaction effect between mangiferin and mogroside,and mogroside can significantly improve anti-inflammatory effect of mangiferin.