Inhibition Effect of Total Alkaloid of Selaginella uncinata(Desv.)Spring on S180 Solid Tumor in Mice
Author(s): SU Heng-hai, SUN Hui-jing, LI Li, ZHOU Jing, Guangxi University of Chinese Medicine, The People’s Hospital of Guangxi Zhuang Autonomous Region
Pages: 646-650
Year: 2015 Issue: 6
Journal: Guangxi Sciences
Keyword: Selaginella uncinata(Desv.)Spring; total alkaloid; anti-tumor; mechanism;
Abstract: 【Objective】The total alkaloid of Selaginella uncinata（Desv.）Spring（TAS）was extracted,and then its inhibition effect on S180 solid tumor in mice and the antitumor mechanism were studied.【Methods】The weight inhibition rate against S180 solid tumor,the expression of NF-κB and COX-2were analyzed in the blank control group,5-FU positive control group,and TAS large and middle dose groups(300mg·kg-1 and 150mg·kg-1 body weight),combined with observation of the sections from different groups.【Results】All the tumor weigh and the NF-κB/COX-2concentration in the TAS high-and mid-dose groups(300mg·kg-1 and 150mg·kg-1)were statistically less than those in the control group（P <0.05 or P <0.01）.【Conclusion】TAS can curb or suppress tumor growth.Its antitumor mechanism is probably to inhibit the expression of NF-κB/COX-2,thereby to inhibit the growth of the blood vessel around the tumor,by which tumor growth is curbed or suppressed.
Pages: 646-650
Year: 2015 Issue: 6
Journal: Guangxi Sciences
Keyword: Selaginella uncinata(Desv.)Spring; total alkaloid; anti-tumor; mechanism;
Abstract: 【Objective】The total alkaloid of Selaginella uncinata（Desv.）Spring（TAS）was extracted,and then its inhibition effect on S180 solid tumor in mice and the antitumor mechanism were studied.【Methods】The weight inhibition rate against S180 solid tumor,the expression of NF-κB and COX-2were analyzed in the blank control group,5-FU positive control group,and TAS large and middle dose groups(300mg·kg-1 and 150mg·kg-1 body weight),combined with observation of the sections from different groups.【Results】All the tumor weigh and the NF-κB/COX-2concentration in the TAS high-and mid-dose groups(300mg·kg-1 and 150mg·kg-1)were statistically less than those in the control group（P <0.05 or P <0.01）.【Conclusion】TAS can curb or suppress tumor growth.Its antitumor mechanism is probably to inhibit the expression of NF-κB/COX-2,thereby to inhibit the growth of the blood vessel around the tumor,by which tumor growth is curbed or suppressed.
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