Achievements and challenge of treatment of electric burn over the past 50 years in China
Author(s): SUN Yong-hua
Pages: 390-392
Year: 2008 Issue: 5
Journal: CHINESE JOURNAL OF BURNS
Keyword: Burns; electric; Surgical flaps; Therapy;
Abstract: For five decades it has been recognized that severe burn injury may precipitate in marked alterations in im-mune function,resulting in life-threatening systemic infections,sepsis,multiple organ failure,and even death.Extensive and deep burns exert widespread and profound impacts on various cells and molecules of the immune system.The general charac-teristics of abnormal immune responses following major burns are hyperinflammatory response and hypoimmune response of innate and adaptive immunity.These are recognized as postbum im-mune dysfunction(PID).The stress reaction,massive necrotic tissue,shock,infection,malnutrition and various therapeutic procedures after burns alter the microenvironment of the immune cells and molecules in which they reside,and consequently re-suit in the changes in immune cells and their secretions in quan.tity and/or activity,and also aberrant signal transduction in dif-ferent immune cells.These events constitute the cellular and molecular ases in the pathogenesis of PID.The main clinical consequences of PID include tissue damages and increased SUS-ceptibility to opportunistic pathogens caused by refractory inflam-mation and suppressed adaptive immunity.In order to decrease the morbidity of these lethal complications,efforts to improve the immune dysfunction after burn injury have been made not only at the integral level of etiological factors,but also at the cellular and molecular levels of its mechanisms.In this review,all these above.mentioned aspects of PID are comprehensively discussed.
Pages: 390-392
Year: 2008 Issue: 5
Journal: CHINESE JOURNAL OF BURNS
Keyword: Burns; electric; Surgical flaps; Therapy;
Abstract: For five decades it has been recognized that severe burn injury may precipitate in marked alterations in im-mune function,resulting in life-threatening systemic infections,sepsis,multiple organ failure,and even death.Extensive and deep burns exert widespread and profound impacts on various cells and molecules of the immune system.The general charac-teristics of abnormal immune responses following major burns are hyperinflammatory response and hypoimmune response of innate and adaptive immunity.These are recognized as postbum im-mune dysfunction(PID).The stress reaction,massive necrotic tissue,shock,infection,malnutrition and various therapeutic procedures after burns alter the microenvironment of the immune cells and molecules in which they reside,and consequently re-suit in the changes in immune cells and their secretions in quan.tity and/or activity,and also aberrant signal transduction in dif-ferent immune cells.These events constitute the cellular and molecular ases in the pathogenesis of PID.The main clinical consequences of PID include tissue damages and increased SUS-ceptibility to opportunistic pathogens caused by refractory inflam-mation and suppressed adaptive immunity.In order to decrease the morbidity of these lethal complications,efforts to improve the immune dysfunction after burn injury have been made not only at the integral level of etiological factors,but also at the cellular and molecular levels of its mechanisms.In this review,all these above.mentioned aspects of PID are comprehensively discussed.
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