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Efects of orbital radiotherapy combined with oral or iv glucocorticoids on the Graves' ophthalmopathy
Author(s): 
Pages: 1135-1137
Year: Issue:  11
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  格雷夫斯病糖皮质激素类药物疗法联合;
Abstract: 目的:观察应用球后放射治疗结合不同给药途径的糖皮质激素联合治疗75例甲状腺眼病的疗效.方法:采用随机、对照、前瞻性研究,比较口服糖皮质激素和脉冲静注糖皮质激素治疗Graves'眼病的比较研究.结果:突眼、眼裂宽度在应用不同的治疗手段后,都有明显的缓解,与治疗前比较差异有显著性(P<0.001).复视在静注糖皮质激素治疗组有31例(81.5%),共有19例(61.3%)在治疗后有明显的疗效;口服糖皮质激素组有29例(78 3%),共有12例(41.3%)在治疗后有明显的疗效,两组间差异有显著性.两组病例经过治疗后,临床活动积分均明显下降,与治疗前对比差异有显著性,静注糖皮质激素治疗组临床活动积分下降更明显,与口服糖皮质激素组对比差异有显著性;但值得关注的是库欣氏征,在口服糖皮质激素组(15例,40.5%)明显高于静注糖皮质激素组(5例,18.4%),二者有明显差异.结论:大剂量脉冲糖皮质激素联合球后放疗治疗Graves'眼病比口服糖皮质激素有更好的疗效,而副作用相对较少,患者更易耐受.
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