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The relationship of serum resistin and plasma glucose, lipidemia as well as insulin resistance in type 2 diabetes
Author(s): 
Pages: 1138-1140
Year: Issue:  11
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  糖尿病Ⅱ型肥胖症血糖高脂血症;
Abstract: 目的:探讨2型糖尿病患者血清抵抗素与血糖、血脂及胰岛素抵抗的关系.方法:52例2型糖尿病(T2DM)患者按体质指数(BMI)分为肥胖(BMI≥25 kg/m2)(26例)与非肥胖(BMI<25 kg/m2)(26例)2组,及17例糖耐量正常的同期健康体检者作为对照组,采用酶联免疫分析法检测空腹血清抵抗素水平;同时行口服葡萄糖耐量(OGTT)和胰岛素释放试验,检测血脂,测量血压、身高、体重、腰围、臀围,计算BMI和腰臀比值(WHR),并以稳态模型(HOMA)计算胰岛素抵抗指数(HOMA-IR).结果:肥胖T2DM患者血清抵抗素水平(ng/mL)明显高于非肥胖T2DM患者(P<0.01);肥胖T2DM组高于对照组、对照组略高于T2DM非肥胖者,但差异无显著性(P>0.05);女性血清抵抗素水平明显高于男性(P<0.05).空腹血清抵抗素与BMI、HOMA-IR呈正相关(r=0.403、r=0.337、P<0.001);与FINS及餐后2hINS呈正相关(r=0.652、r=0.428、P<0.001);与甘油三酯呈正相关(r=0.320、P<0.01);与空腹血糖无关而与餐后2h血糖呈负相关(r=-0.303,P<0.05),抵抗素与血压、WHR、年龄、胆固醇、高密度脂蛋白、低密度脂蛋白无明显相关性(P>0.05).结论:肥胖T2DM患者血清抵抗素水平升高,血清抵抗素与BMI、空腹胰岛素、餐后2 h胰岛素、餐后2 h PG、HOMA-IR及甘油三酯有关,抵抗素可能参与了肥胖T2DM胰岛素抵抗的形成,并加重T2DM患者甘油三酯异常.
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