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bing du xing nao yan huan er xue qing nao ji ye tnf- he sicam-1 de bian hua
Author(s): 
Pages: 1180-1181
Year: Issue:  11
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  脑炎病毒性儿童肿瘤坏死因子;
Abstract: 目的:测定病毒性脑炎(VE)患儿血清、脑脊液治疗前后肿瘤坏死因子-α(TNF-α)和可溶性细胞间黏附分子-1(sICAM-1)水平,探讨其在发病中的意义.方法:采用ELISA法测定38例VE患儿治疗前后血清、脑脊液TNF-α和sICAM-1水平,并与正常对照组比较.结果:治疗前轻症组和重症组血清、脑脊液TNF-α和sICAM-1水平均较对照组明显升高(P均<0.01),且重症组较轻症组明显升高(P均<0.01);治疗后重症组TNF-α和sICAM-1水平仍高于正常对照组,差异有显著性意义(P<0.05,P<0.01),轻症组治疗后TNF-α、sICAM-1水平高于对照组,但差异无显著性意义(P均>0.05).结论:VE患儿治疗前血清和脑脊液TNF-α和sICAM-1水平显著升高,病情越重升高越明显.
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