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Effects of procainamide on transmural ventricular repolarisation
Author(s): 
Pages: 1371-1374
Year: Issue:  11
Journal: CHINESE PHARMACOLOGICAL BULLETIN

Keyword:  心脏电生理复极激动恢复间期普鲁卡因胺心肌;
Abstract: 目的研究普鲁卡因胺对心室跨壁复极时间的影响.方法对6只绵羊用苯巴比妥麻醉后,开胸,用4个针状(plunge needles)电极分别插入到左心室的基底部和心尖部,测量室壁激动-恢复间期(ARI).静脉注射普鲁卡因胺20 mg·min-1后观察ARI的变化.结果窦性心律时,心外膜、中层心肌和心内膜的ARI差异无显著性,[分别为(266.0±30.5 )ms、(265.0±28.9) ms和(265.7±28.1) ms,P>0.05].普鲁卡因胺对各层心肌的ARI均有延长作用,心外膜、中层心肌和心内膜的ARI分别延长了(66.8±18.3) ms、 (70.3±14.7) ms和 (65.3±15.7) ms(P>0.05).结论钠通道阻滞剂普鲁卡因胺对左室的心外膜、中层心肌和心内膜复极的延长程度相似.
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