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Elastase inhibitor produced by Micromonospora sp. FIM99468 Ⅰ. Taxonomy, fermentation, isolation and biological activity
Pages: 577-
580
Year: 2005
Issue:
10
Journal: CHINESE JOURNAL OF ANTIBIOTICS
Keyword: 弹性蛋白酶抑制剂; 小单孢菌; 生物学活性;
Abstract: 在筛选弹性蛋白酶抑制剂过程中,从福建省永泰青云山土壤中分离到放线菌FIM99468,经分类鉴定为佛罗里达小单孢菌,定名为Micromonospora floridensis FIM99468.经发酵、提取,产生的次级代谢产物Fw99468能够抑制弹性蛋白酶,半数抑制浓度IC50为3.4×10-6mol/L.
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