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Clinical characteristics of drug therapy in renal transplant recipients with hepatitis B and C virus infection
Author(s): 
Pages: 663-665
Year: Issue:  10
Journal: CHINESE JOURNAL OF UROLOGY

Keyword:  肾移植肝炎病毒;
Abstract: 目的探讨血清肝炎病毒标志物阳性肾移植患者术后临床用药特点.方法40例同种异体肾移植患者,男22例,女18例.年龄30~56岁.其中乙型肝炎感染29例、丙型肝炎感染9例、乙型肝炎合并丙型肝炎感染2例.患者肝功能正常,随机分为普乐可复组(n=20),环孢素A组(n=20).观察患者术后肝、肾功能情况及人/肾存活率.结果40例患者术后随访2年,普乐可复组肝功能异常发生率、急性排斥反应发生率明显低于环孢素A组(分别为15%vs 30%,5%vs20%),2组2年人/肾存活率均为100%.结论血清肝炎病毒标志物阳性患者接受肾移植术后首选普乐可复作为基础免疫制剂方案,可减少排斥反应发生率,对肝脏的损害程度轻.
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