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The Alteration of Atrial Structure and Electrophysiological Characteristics in Abdominal Aorta Banded Rats
Author(s): 
Pages: 560-563
Year: Issue:  9
Journal: CHINESE JOURNAL OF HYPERTENSION

Keyword:  心房纤维化电生理心房颤动肾素血管紧张素系统高血压;
Abstract: 目的研究腹主动脉结扎大鼠心房结构和电生理特征变化,探讨高血压相关性房颤的发病机制.方法雄性SD大鼠随机分为非手术组(对照组,n=12)和腹主动脉结扎组(实验组,n=12),两组喂养时间均为4周.4周后动物麻醉,描记I导体表心电图,经左侧颈总动脉插管测量收缩压和舒张压.在心脏体外灌流条件下,采用心房短阵刺激评价房间传导时间(IACT)和心房对刺激的反应.取心房组织制作切片,Masson染色,测量纤维组织占总区域的百分比.结果实验组血清 Ang Ⅱ水平较对照组明显升高[(1.76±0.5 vs 0.97±0.4)ng/mL,P<0.01], P波持续时间和IACT也较对照组延长[分别为(27.8±5.1 vs 23±4.5)ms, P<0.05和(37.3±5 vs 23.1±3.3)ms,P<0.01],在实验组诱发出4例AF;对照组没能诱发出AF.组织学发现实验组心房纤维组织明显增加,纤维化程度与AF的诱发有相关性(OR=5.75,P<0.01).结论腹主动脉结扎大鼠心房纤维化程度增加,P波时限增宽,IACT延长,心房有效不应期没有改变.心房纤维化程度增加可能是AF诱发率升高的原因.
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