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The Analysis of the change about Intestinal Mucosal Barrier in Severe Acute Pancreatitis
Author(s): 
Pages: 903-905
Year: Issue:  9
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  胰腺炎急性坏死性肠黏膜内毒素肿瘤坏死因子二胺氧化酶一氧化氮;
Abstract: 目的:探讨急性重症胰腺炎 (SAP)的肠道黏膜屏障功能改变的机制,以期提高对 SAP的治疗策略.方法: 36例 SAP患者入院当天采血检测二胺氧化酶 (DAO)、内毒素 (endotoxin, ET)、肿瘤坏死因子 (TNF-α )、一氧化氮 (NO)的浓度.并用带特殊电化学检测器的高压液相色谱法 (HPLC)检测尿中乳果糖与甘露醇排泄率比值.以 30名健康志愿者作为正常对照组.结果:同正常对照组相比较, SAP患者尿中乳果糖与甘露醇排泄率比值明显升高 (P< 0.01);血中 ET、 NO、 TNFα、 DAO 的水平显著增加 (P< 0.01).结论:急性重症胰腺炎患者的肠黏膜屏障受损,肠黏膜通透性增高. ET、 NO、 TNFα单独或协同参与肠黏膜屏障的损害. DAO升高提示肠道黏膜的完整性受到破坏.
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