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Effects of Astragalus polysaccharide and total glucosides of paeony on synergistic antiplatelet aggregation in rabbits
Author(s): 
Pages: 932-934
Year: Issue:  8
Journal: CHINESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Keyword:  黄芪多糖白芍总苷血小板聚集均匀设计协同作用;
Abstract: 目的:研究黄芪多糖(Astragalus polysaccharide,APS)对血小板聚集功能的作用,并探索其与白芍总苷(total glucosides of paeony,TGP)最佳剂量配比.方法:比浊法测量家兔血小板聚集功能;用均匀设计两因素五水平的实验安排方法观察黄芪多糖和白芍总苷的最佳配伍剂量.结果:黄芪多糖对二磷酸腺苷(ADP)引起的血小板聚集有抑制作用(P<0.01),其与白芍总苷的最佳配伍剂量为121.结论:黄芪多糖和白芍总苷对血小板聚集有协同抑制作用,为中药复方的临床应用提供药理学基础.
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