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Effects of carbamazepine on evoked potentials and its clinical significance
Author(s): 
Pages: 8-9
Year: Issue:  6
Journal: JOURNAL OF PRACTICAL NERVOUS DISEASES

Keyword:  卡马西平癫癎诱发电位;
Abstract: 目的研究长期口服卡马西平治疗癫癎对诱发电位的影响,并讨论其意义.方法选择尚未治疗的癫癎病人31例作为试验组;以性别、年龄与癫癎组相匹配的健康正常人26例作为对照组.两组先分别做脑干听觉诱发电位(BAEP)、事件相关电位P300、视觉诱发电位(VEP)和体感诱发电位(SEP),之后癫癎组开始卡马西平治疗,服药一年后再作上述各项检查.结果癫癎组病人治疗前各项电生理学指标与正常对照组相比无显著性差异;癫癎组卡马西平治疗后各项电生理指标与治疗前相比BAEP各波、P300以及VEP的P100波潜伏期均显著延长;SEP的潜伏期无显著变化.结论神经电生理学检查可以早期发现长期服用卡马西平导致的亚临床毒性.
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