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Effect of valsartan on pulmonary artery smooth muscle cell hyperplasia in pulmonary hypertension rats
Author(s): 
Pages: 456-457
Year: Issue:  5
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  高血压肺性 细胞 增生 缬氨酸;
Abstract: 目的:探讨缬沙坦降压和对肺高压大鼠肺血管平滑肌细胞增生的影响.方法:对分流组及治疗组大鼠行腹主动脉-下腔静脉分流术,治疗组以缬沙坦40 mg/(kg·d)灌胃.术后 6周和 11周分别测定肺动脉平均压(PAMP)、心室 (RV)/左心室+室间隔 (LV+S)比值,观察肺血管壁的变化.结果:治疗组大鼠术后6周和11周 PAMP、RV/LV+S及肺血管平滑肌细胞增生程度均比分流组为轻.结论:缬沙坦有降低肺高压大鼠肺动脉压力,减轻肺血管平滑肌细胞增生的作用.
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