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ru xian ai vegf-c de biao da yu lin ba guan sheng cheng de guan xi ji yi yi
Author(s): 
Pages: 470-471
Year: Issue:  5
Journal: THE JOURNAL OF PRACTICAL MEDICINE

Keyword:  内皮生长因子内皮淋巴管乳腺肿瘤淋巴转移;
Abstract: 目的:探讨血管内皮生长因子C( vascular endothelial growth factor C ,VEGF-C)在乳腺癌淋巴管生成及其与淋巴结转移中的作用.方法:采用免疫组织化学染色非生物素检测系统 Polymer两步法,检测 52例乳腺癌组织标本、16例正常乳腺组织 VEGF-C的表达;应用酶组织化学方法检测癌周微淋巴管密度( microlymphatic vessel density,MLVD).结果:乳腺癌 VEGF-C的表达率为 71.15%,显著高于正常对照组的 12.50%( P<0.025);乳腺癌MLVD为 22.32± 5.36,显著高于正常对照组的6.52±2.28(P< 0.001),MLVD与VEGF-C的表达具有显著正相关性(P=0.007);并且,VEGF-C的表达与淋巴结转移呈正相关,P=0.013.结论:VEGF-C在乳腺癌淋巴管生成及其淋巴结转移中具有重要作用.
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