The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit
later.
We apologize for any inconvenience caused
Influence of Imiquimod on Cytokine Induction in BALB/c Mice
Author(s): ZHOU Xiao-Yong, LI Xin-yu, ZHENG Jia-run
Pages: 271-
272
Year: 2005
Issue:
5
Journal: CHINESE JOURNAL OF DERMATOLOGY
Keyword: 咪喹莫特; 白细胞介素12; 白细胞介素4; 干扰素α; 动物替代试验;
Abstract: 目的探讨咪喹莫特的免疫调节机制.方法ELISA检测经咪喹莫特灌胃(30 mg/kg)后不同时间点的BALB/c小鼠血清干扰素α(IFN-α)、白介素12(IL-12)、干扰素γ(IFN-γ)、白介素4(IL-4)浓度的变化.ELISA检测喂食咪喹莫特的BALB/c小鼠脾细胞在与0.25μg/mL刀豆素A共孵育时分泌IFN-γ、IL-4的能力.结果咪喹莫特体内诱导BALB/c小鼠生成IFN-α、IL-12,在诱导后2 h达高峰;咪喹莫特体内无诱导BALB/c小鼠生成IFN-γ、IL-4的作用;接受咪喹莫特灌胃的BALB/c小鼠脾细胞体外受ConA诱导时,分泌IFN-γ和IL-12的能力增强.结论咪喹莫特诱导BALB/c小鼠分泌IFN-α、IL-12等前炎症因子,并由此促进机体获得性免疫.
Citations
No citation found