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Correlative Study on Liver-Depression Pathogenesis and Gonadal Axis Function in Women with Infertility
Author(s): 
Pages: 36-38
Year: Issue:  3
Journal: ACTA UNIVERSITATIS TRADITIONIS MEDICALIS SINENSIS PHARMACOLOGIAEQUE SHANGHAI

Keyword:  不孕症肝郁/病理性激素;
Abstract: 目的探讨不孕症肝郁病理与性腺轴功能变化的相关性.方法选择原发性不孕症患者70例,健康对照19例,以辨证分型、肝郁积分、性激素检测为指标.结果 (1)不孕症以兼夹证多见,其中肝郁证、肾虚证所占比例为高(P<0.01).(2)不同证型组肝郁病变程度均显著高于对照组(P<0.01).(3)月经周期第10天,各证型组雌二醉(E2)均显著高于对照组(P<0.05或P<0.01);肝郁组、肾虚组孕酮(P)显著高于对照组(P<0.01);肝郁组、痰湿组、血瘀组泌乳素(PRL)均显著高于对照组(P<0.05或P<0.01).月经周期第20天,肝郁组、肾虚组、痰湿组P显著低于对照组(P<0.01);不同证型组P/E2均显著低于对照组(P<0.05或P<0.01).(4)月经周期第10天,PRL与E2呈负相关(P<0.05);PRL与P呈负相关(P<0.01);PRL与P/E2呈负相关(P<0.01);PRL与LH呈正相关(P<0.05).月经周期第20天,肝郁分级与PRL呈正相关(P<0.05).结论 PRL增高,继而干扰下丘脑-垂体-卵巢轴的功能,导致排卵障碍是不孕症肝郁的病理机制.
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