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Flow Cytometry Study of the Effect of "Qing chang Suppository" on Rat with Ulcerative Colitis
Author(s): 
Pages: 42-44
Year: Issue:  3
Journal: ACTA UNIVERSITATIS TRADITIONIS MEDICALIS SINENSIS PHARMACOLOGIAEQUE SHANGHAI

Keyword:  清肠栓溃疡性结肠炎大鼠结肠上皮细胞凋亡率;
Abstract: 目的观察中药清肠栓对实验性溃疡性结肠炎大鼠结肠上皮细胞凋亡率的影响,探讨其作用机制.方法用三硝基苯磺酸制备大鼠实验性溃疡性结肠炎模型,随机分为模型组、SASP组、清肠栓组、正常对照组,给药7 d后处死,剪取远端结肠,流式细胞仪检测结肠上皮细胞凋亡率.结果正常组、SASP组与清肠栓组的结肠上皮细胞凋亡率均较模型组明显降低,差异均有非常显著性意义(P<0.01),清肠栓组凋亡率的平均值较SASP组凋亡率的平均值低,但两组凋亡率的差异没有统计学意义(P>0.05).结论中药清肠栓治疗溃疡性结肠炎的作用机理与降低结肠上皮细胞凋亡率有关.
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